- Case Report
- Graves disease following rabbit antithymocyte globulin treatment of severe aplastic anemia in a Korean child
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In Su Choi, Han Kyul Kim, Dong Kyun Han, Hee Jo Baek, Hae In Jang, Chan Jong Kim, Hoon Kook
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Clin Exp Pediatr. 2015;58(7):267-269. Published online July 22, 2015
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Antithymocyte globulin (ATG) is used as an immunosuppressive treatment (IST) to deplete clonal suppressor T cells in patients with severe aplastic anemia (SAA). The depletion of suppressor T cells by ATG may affect the activation of B cells, which results in an increased risk for autoimmune conditions. A 12-year-old boy was diagnosed with idiopathic SAA. As he did not have... |
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- Alveolar rhabdomyosarcoma with massive disseminated intravascular coagulopathy treated with systemic chemotherapy
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Byung Gyu Yoon, Hee Jo Baek, Burm Seok Oh, Dong Kyun Han, Yoo Duk Choi, Hoon Kook
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Clin Exp Pediatr. 2015;58(12):505-508. Published online December 22, 2015
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It is uncommon for pediatric patients with rhabdomyosarcoma to present with clinical and/or laboratory features of disseminated intravascular coagulation (DIC). We report a case of metastatic alveolar rhabdomyosarcoma with severe bleeding because of DIC in a 13-year-old boy. He experienced persistent oozing at the site of a previous operation, gross hematuria, and massive epistaxis. Two weeks after initiating combination chemotherapy... |
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- Original Article
- Long-term follow-up of Fanconi anemia: clinical manifestation and treatment outcome
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Byung Gyu Yoon, Hee Na Kim, Ui Joung Han, Hae In Jang, Dong Kyun Han, Hee Jo Baek, Tai Ju Hwang, Hoon Kook
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Clin Exp Pediatr. 2014;57(3):125-134. Published online March 31, 2014
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Purpose The aim of this study was to characterize Korean patients with Fanconi anemia (FA), which is a rare but very challenging genetic disease. MethodsThe medical records of 12 FA patients diagnosed at Chonnam National University Hospital from 1991 to 2012 were retrospectively reviewed. ResultsThe median age at diagnosis was 6.2 years. All patients showed evidence of marrow failure and one or more... |
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- Selective embolization of the internal iliac arteries for the treatment of intractable hemorrhage in children with malignancies
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Sul Hee Bae, Dong Kyun Han, Hee Jo Baek, Sun Ju Park, Nam Kyu Chang, Hoon Kook, Tai Ju Hwang
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Clin Exp Pediatr. 2011;54(4):169-175. Published online April 30, 2011
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Purpose Acute internal hemorrhage is an occasionally life-threatening complication in pediatric cancer patients. Many therapeutic approaches have been used to control bleeding with various degrees of success. In this study, we evaluated the efficacy of selective internal iliac artery embolization for controlling acute intractable bleeding in children with malignancies. MethodsWe retrospectively evaluated the cases of 6 children with various malignancies (acute lymphoblastic... |
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- Comparison of total body irradiation-based or non-total body irradiation-based conditioning regimens for allogeneic stem cell transplantation in pediatric leukemia patients
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Sang Jeong Kim, Dong Kyun Han, Hee Jo Baek, Dong Yeon Kim, Taek Keun Nam, Tai Ju Hwang, Hoon Kook
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Clin Exp Pediatr. 2010;53(4):538-547. Published online April 15, 2010
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Purpose : This study aims to compare the outcome of total body irradiation (TBI)- or non-TBI-containing conditioning regimens for leukemia in children.
Methods : We retrospectively evaluated 77 children conditioned with TBI (n=40) or non-TBI (n=37) regimens, transplanted at Chonnam National University Hospital between January 1996 and December 2007. The type of transplantation, disease
status at the time of transplant, conditioning regimen,... |
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- Thrombotic thrombocytopenic purpura with decreased level of ADAMTS-13 activity and increased level of ADAMTS-13 inhibitor in an adolescent
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Eun Mi Yang, Dong Kyun Han, Hee Jo Baek, Young Ok Kim, Myung Geun Shin, Hoon Kook, Tai Ju Hwang
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Clin Exp Pediatr. 2010;53(3):428-431. Published online March 15, 2010
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Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy characterized by endothelial cell damage, resulting in microangiopathic hemolytic anemia, thrombocytopenia, and various degrees of neurological and renal impairment caused by microvascular thrombi. It is rare in children and frequently follows a fatal course. TTP is divided into 2 types: one is inherited and associated with ADAMTS-13 gene mutations and the other... |
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- Case Report
- A case of atypical hemolytic uremic syndrome as an early manifestation of acute lymphoblastic leukemia
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Dong Kyun Han, Hee Jo Baek, Young Kuk Cho, Chan Jong Kim, Myung Geun Shin, Hoon Kook, Tai Ju Hwang
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Clin Exp Pediatr. 2010;53(2):253-257. Published online February 15, 2010
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Hemolytic uremic syndrome (HUS) is the most common cause of acute renal failure in children younger than 4 years and is characterized by microangiopathic hemolytic anemia, acute renal failure, and thrombocytopenia. HUS associated with diarrheal prodrome is usually caused by Shiga toxin-producing Escherichia coli O157:H7 or by Shigella dysenteriae, which generally has a better outcome. However, atypical cases show a... |
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- Perivascular epithelioid cell tumor (PEComa) of the ascending colon: the implication of IFN-α2b treatment
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Sun Ju Park, Dong Kyun Han, Hee Jo Baek, Sang Young Chung, Jong Hee Nam, Hoon Kook, Tai Ju Hwang
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Clin Exp Pediatr. 2010;53(11):975-978. Published online November 30, 2010
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A 7-year-old boy presented with hematochezia and abdominal pain. A 3.7-cm-sized mass was identified in the ascending colon by abdominal computed tomography and colonoscopy. The patient underwent surgical resection. Pathological examination revealed a low-grade perivascular epithelioid cell tumor (PEComa). PEComa in the colon is very rare. Only a few cases have been reported so far. An effective treatment method for... |
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- Facial palsy as the presenting symptom of acute myeloid leukemia
in children: Three cases with stem cell transplantatio
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Hee Jo Baek, Dong Kyun Han, Young Ok Kim, Ic Sun Choi, Tai Ju Hwang, Hoon Kook
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Clin Exp Pediatr. 2009;52(6):713-716. Published online June 15, 2009
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Facial palsy as the presenting symptom of leukemia is very rare, especially in acute myeloid leukemia. A review of the medical literature identified reports on 8 children with AML who had facial paralysis as the presenting sign. Whole brain irradiation (WBI) has been applied in most cases. We present the cases of 3 such children. Achieving a remission without WBI,... |
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- Late adverse reactions to iopromide (Ultravist®) diagnosed by the patch test: a case report
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Soon Joo Lee, Eun Mi Yang, Woo Yeon Choi, Eun Song Song, Dong Kyun Han, Young Kuk Cho, Jae-Sook Ma
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Clin Exp Pediatr. 2009;52(4):499-503. Published online April 15, 2009
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Iodinated contrast media (CM) can cause immediate and late reactions. We treated a patient with a recurrent generalized maculopapular rash and a fever that occurred within two days of exposure to iodinated CM, iopromide (UltravistⓇ), for chest computed tomography. We performed skin testing including prick tests, intradermal tests, and patch tests. Our findings indicated a late skin reaction to Ultravist¢cin... |
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- Wilms` tumor, aniridia, genitourinary anomalies, and mental retardation (WAGR) syndrome: Successful treatment of the first case with
bilateral Wilms` tumors in Korea
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Kyung Sun Min, Hee Jo Baek, Dong Kyun Han, Ju Hee You, Tai Ju Hwang, Dong Deuk Kwon, Hoon Kook
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Clin Exp Pediatr. 2008;51(12):1355-1358. Published online December 15, 2008
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Wilms` tumor, aniridia, genitourinary anomalies, and mental retardation (WAGR) syndrome is caused by deletion of chromosome 11p13, including the Wilms` tumor (WT1) and aniridia gene (PAX6) loci. Here, we report the first case of WAGR syndrome in Korea; the patient was a 2-year-old girl with bilateral aniridia from birth who presented with abdominal distention and mental retardation. Cytogenetically, she had... |
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- A case of vancomycin-induced drug hypersensitivity syndrome
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Kyung Sun Min, Woo Yeon Choi, Eun Song Song, Dong Kyun Han, Young Kuk Cho, Jae Sook Ma
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Clin Exp Pediatr. 2008;51(11):1228-1231. Published online November 15, 2008
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Drug hypersensitivity syndrome (DHS) has rarely been reported in association with vancomycin treatment. Here, we describe an 11-year-old girl who developed fever and a maculopapular rash on day 18 of intravenous vancomycin for treatment of infective endocarditis. The patient presented with fever, a maculopapular skin rash, hepatitis, and acute renal failure caused by vancomycin-induced DHS. The symptoms resolved in less... |
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- The clinical phenotype of the derivative (8)t(7;8)(q22;p23.3) in two siblings
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Young Ok Kim, Young Kuk Cho, En Song Song, Dong Kyun Han, Ic Sun Choi, Hee Jo Baek, Chan Jong Kim, Young Jong Woo, Young Youn Choi
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Clin Exp Pediatr. 2008;51(11):1241-1244. Published online November 15, 2008
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We report on 2 siblings with a partial trisomy of 7q (7q22→qter) and concomitant partial monosomy of 8p (8p23.3→pter), which were shown by FISH using probes located at the telomere region of each chromosome. All the balanced translocation carriers (father and a sister) in this family had a normal phenotype. The 2 siblings with the same abnormal karyotype had similar... |
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- Original Article
- Comparison of growth and neuropsychological function after treatment for hematologic and oncologic diseases in monozygotic twins
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Gi Hwan Kim, Hoon Kook, Hee Jo Baek, Dong Kyun Han, Eun Song Song, Young Kook Jo, Ic Sun Choi, Young Ok Kim, Chan Jong Kim, Young Jong Woo, Soo Jin Yang
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Clin Exp Pediatr. 2007;50(2):182-189. Published online February 15, 2007
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Purpose : The primary purpose of this study was to evaluate the growth and neuropsychologic function following treatments for pediatric hematologic and oncologic diseases. Healthy monozygotic twins served as ideal controls for comparison to exclude possible confounding factors.
Methods : Seven children treated with various hematologic and oncologic diseases were included in the study: acute lymphoblastic leukemia (ALL; n=2), Diamond-Blackfan anemia... |
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- Case Report
- Two Cases of Paragonimiasis in Young Siblings Presenting with Pleural Effusion and Subcutaneous Nodules
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Moon Young Jeong, Hee Jo Baek, Duck Cho, Jin Kim, Chan Kyoo Hwang, Dong Kyun Han, Jae Sook Ma, Hoon Kook
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Clin Exp Pediatr. 2005;48(12):1385-1388. Published online December 15, 2005
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Paragonimiasis is the infestation of lung flukes of the trematode genus Paragonimus. This disease is common in Asia, and the southern part of Korea has been known as one of the endemic areas of Paragonimiasis westermanii in Korea. Human infection is associated with specific dietary habits, such as eating freshwater crawfish or crabs. In a 6 1/2-year-old boy with pleural... |
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